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|
Compound/drug and conc.
|
Mean motility scores over a period of 40 days
|
Motility
|
MTT
|
|---|
|
DAY
|
1
|
5
|
10
|
15
|
20
|
25
|
30
|
35
|
40
|
% reduction on day 40 (P)
|
% inhibition on day 40 (P)
|
|
Control
|
8.0
|
7.4
|
7.1
|
7.0
|
5.3
|
5.5
|
6.3
|
6.4
|
4.9
| | |
|
CGP 6140 1.25 × 10-5M (positive control)
|
0.5
|
0.8
|
0.0
|
0.5
|
0.0
|
0.0
|
0.0
|
0.0
|
0.0
|
100.0 (0.005)
|
83.3 (0.098)
|
|
Rifampicin 5 × 10-5M
|
7.7
|
6.8
|
6.7
|
6.8
|
3.2
|
1.7
|
0.2
|
0.2
|
0.0
|
100.0 (0.002)
|
89.6 (0.033)
|
|
Rifampicin 1.25 × 10-5M
|
7.0
|
7.0
|
7.3
|
5.7
|
6.5
|
5.2
|
5.7
|
5.0
|
5.6
|
0.0 (0.647)
|
0.0 (0.798)
|
|
Minocycline 5 × 10-5M
|
8.0
|
6.7
|
7.3
|
5.7
|
0.0
|
0.0
|
0.0
|
0.0
|
0.0
|
100.0 (0.002)
|
84.1 (0.042)
|
|
Minocycline 1.25 × 10-5M
|
7.8
|
7.5
|
6.7
|
5.7
|
4.3
|
2.5
|
4.8
|
1.7
|
0.0
|
100.0 (0.002)
|
93.7 (0.026)
|
|
Doxycycline 5 × 10-5M
|
8.3
|
8.0
|
8.0
|
5.7
|
0.3
|
0.0
|
0.0
|
0.0
|
0.0
|
100.0 (0.002)
|
93.0 (0.027)
|
|
Doxycycline 1.25 × 10-5M
|
7.3
|
6.5
|
6.3
|
4.8
|
6.3
|
6.3
|
6.2
|
6.2
|
5.5
|
0.0 (0.699)
|
0.0 (0.801)
|
|
Ethambutol 5 × 10-5M
|
6.8
|
6.8
|
6.5
|
6.7
|
4.0
|
4.8
|
4.3
|
5.0
|
2.7
|
44.9 (0.170)
|
73.0 (0.108)
|
|
Dapsone 5 × 10-5M
|
7.3
|
7.3
|
7.7
|
5.0
|
6.8
|
7.0
|
7.2
|
7.3
|
6.5
|
0.0 (0.250)
|
0.0 (0.798)
|
|
Pyrazinamide 5 × 10-5M
|
7.7
|
7.7
|
7.2
|
3.5
|
5.5
|
5.5
|
5.7
|
5.2
|
3.7
|
24.5 (0.503)
|
4.8 (0.949)
|
- The effects of exposure to a range of antibiotics on the viability of Onchocerca gutturosa adult males in long-term (40 day) in vitro culture. Viability was assessed by measuring worm motility scores throughout the trial and by MTT colorimetry on day 40.
